You can use the Calculate Fields node to set a default value if a field is Null.
For example, the default data in the Create Data node includes Null values in a number of fields:

The data quality bars in the field header area indicate the data is not complete.
In the Calculate Fields node define calculated fields with the same name and data type as the input field. Define the Expression for the calculated field to be the input field.

As the name of the calculated field already exists in the input data, the existing field is replaced by the calculated value. For records where the field is not Null, the data is effectively unchanged. However, if the field value is Null, the default value *for that data type* is substituted into the output field. The default value is set using the Optional DefaultValueFor... properties:

Note that only a single default value can be defined for each data type in a particular node and will be used for all calculations that include fields with that data type. If you want to have different defaults for different fields then you can use multiple Calculate Fields nodes in series - specifying the required default values and corresponding input fields in each node.
Here is the effect of applying the expressions shown above:

As no default values were defined in the node's properties, the default values are used (False for Boolean fields, the epoch for dates and datetime fields and 00:00:00 for time fields). Input fields that are not specified in the node are passed through unchanged.