These 2 web articles explain how the choice of geographies (ZIPCODES) to analyze for the Flint, MI contaminated water problem exacerbated the problem and emphasizes the importance of choosing the correct geographies for analysis:
https://www.gislounge.com/quirky-geography-zip-codes-obscured-flints-lead-problem/
http://theconversation.com/how-zip-codes-nearly-masked-the-lead-problem-in-flint-65626