WARNING / TOP TIP:
If you upgrade to SSA 12.2.1 (the latest patch), ensure you make a back up of Program Files\Pitney Bowes\SpectrumSpatialAnalyst\ before upgrading.
I found that all map layer that had painstakingly been assigned to custom templates in Admin Console had bounced back to the default template after 12.2.1 was installed.
I'm waiting on it to be confirmed by PB, but I strongly suspect this is a bug in 12.2.1 (I'm happy to stand corrected, of course).
Fortunately you can recover the situation by using a file from your Program Files\Pitney Bowes\SpectrumSpatialAnalyst\ back up.
After upgrading to 12.2.1 take a copy of CalloutInfoTemplateDefinitions.xml in your back of Program Files\Pitney Bowes\SpectrumSpatialAnalyst\customerconfigurations\analyst and place into your live Program Files\Pitney Bowes\SpectrumSpatialAnalyst\customerconfigurations\analyst folder, replacing the new one in 12.2.1.
Your custom template mappings will return. Or at least it did for me!